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GW 627368X

CAS No. 439288-66-1

GW 627368X( GW627368X | GW 627368X | GW-627368X | GW627368 )

Catalog No. M14493 CAS No. 439288-66-1

GW627368(GW627368X) is a novel, potent and selective competitive antagonist of prostanoid EP4 receptor(Ki= 100 nM) with additional human TP receptor affinity(Ki= 150 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    GW 627368X
  • Note
    Research use only, not for human use.
  • Brief Description
    GW627368(GW627368X) is a novel, potent and selective competitive antagonist of prostanoid EP4 receptor(Ki= 100 nM) with additional human TP receptor affinity(Ki= 150 nM).
  • Description
    GW627368(GW627368X) is a novel, potent and selective competitive antagonist of prostanoid EP4 receptor(Ki= 100 nM) with additional human TP receptor affinity(Ki= 150 nM).
  • In Vitro
    ——
  • In Vivo
    Animal Model:6-8 weeks Swiss albino mice Dosage:0 mg/kg, 5 mg/kg, 10 mg/kg, 15 mg/kg, 15 mg/kg Administration:Oral administration, every alternate day for 28 days Result:Displayed anti-tumor and anti-proliferative potential in sarcoma 180 bearing mice.
  • Synonyms
    GW627368X | GW 627368X | GW-627368X | GW627368
  • Pathway
    GPCR/G Protein
  • Target
    Prostaglandin Receptor
  • Recptor
    EP4
  • Research Area
    Inflammation/Immunology
  • Indication
    ——

Chemical Information

  • CAS Number
    439288-66-1
  • Formula Weight
    544.62
  • Molecular Formula
    C30H28N2O6S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 10 mg/mL
  • SMILES
    O=C(NS(=O)(C1=CC=CC=C1)=O)CC2=CC=C(N(CC3=C4C(OCC)=C(C=CC=C5)C5=C3OCC)C4=O)C=C2
  • Chemical Name
    2-(4-(4,9-diethoxy-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)phenyl)-N-(phenylsulfonyl)acetamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Wilson RJ, et al. Br J Pharmacol. 2006 Jun; 148(3): 326-39.
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